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Kivexa is an antiviral medication based on a combination of two different nucleoside reverse-transcriptase inhibitors: abacavir - indicated to treat HIV-1 infections and lamivudine - an inhibitor of both HIV-1 and HIV-2 reverse transcriptase.
HIV affects human immune system by annihilating CD4 T-helper lymphocytes. The virus produces the viral RNA which becomes embedded into our DNA; this process occurs in the presence of reverse intracellular enzymes. After being metabolized, abacavir and lamivudine come to act as active monophosphate metabolites which set in the viral DNA chain and break it, while blocking the action of reverse intracellular enzyme. The desired effect of the chain terminator of DNA synthesis and inhibitor of HIV reverse transcriptase enzyme is to impede further viral progression.
Kivexa has been designed as an antiretroviral drug and should be used as part of the standard combination therapy used in HIV patients. The targeted patient should be older than 12.
Do not undergo a treatment with Kivexa if any of the following circumstances / criteria applies:
- Hypersensitivity to any components of the preparation, including active and non-active ingredients;
- Patient is under 12 years of age or under 40 kg/88 lbs;
- Severe liver function insufficiency.
Use Kivexa with caution of the patient presents any of the following symptoms/health issues:
- Liver problems: hepatomegaly (liver larger than normal); mild to moderate liver function insufficiency; hepatitis; other liver disease; history of alcoholism and/or alcohol abuse;
- Kidney problems such as kidney function insufficiency;
- Raised cholesterol levels, obesity, and other risk factors for cardiologic conditions;
Improper use of antiretroviral drugs can lead to mutations featuring resistance to multiple drugs. Do not take Kivexa unless under roper supervision by a professional health care provider aware of your condition.
Pharmaceutical medication may result in the occurrence of certain side-effects that may manifest differently in different patients based on a number of factors which are mostly related to the specific traits of each individual. Here is a list of the most severe and frequent side effects of Kivexa as acknowledged by the drug manufacture. Please note that this is not an exhaustive list and does not encompass all the possible side effects of Kivexa.
- tonus and sleep issues: fatigue or lethargy; insomnia;
- flu symptoms: nasal symptoms; cough; fever;
- digestive effects: diarrhea; abdominal pain; loss of appetite;
- joint pain; muscle pain;
- hair loss.
For more comprehensive information on the health risks and potential adverse effects associated with the use of Kivexa, please consult your doctor, read the package leaflet of Kivexa carefully, or contact our customer support team.
We strongly advise you to inform your doctor of any other medication you may be using, including prescription and over the counter drugs, before using Kivexa. Please check the safety of any combination therapy with Kivexa you may be following and consult your doctor regarding drug interaction when in doubt. The following drugs or groups of drugs are likely to interact with the use of Kivexa and should therefore not be used in combination with Kivexa. Make sure to mention any of these to your doctor or pharmacist:
- medication belonging in the pharmaceutical class of synthetic guanine derivatives (antiviral medication such as zalcitabine, foscarnet, and gancyclovir);
- retinoid medication
- Bstatics such as trimethoprim;
- CYP isoenzymes, including CYP3A4, CYP2D6, etc.
- synthetic opioides
- lamuvidine or other TC medication
Kivexa medication is thought to be less effective when used with Phenobarbital, phenytoin, rifarmpicin, or other barbitulates.
Kivexa is not to be shared with others: do not offer your prescription medication to other individuals; do not use Kivexa to treat a condition other than those related to the drug indications. The product must be kept out of the reach of children.
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